Monocytes Chat With Atherosclerotic Lesions
نویسندگان
چکیده
منابع مشابه
Monocytes Chat With Atherosclerotic Lesions.
Atherosclerotic vascular disease is a chronic inflammation characterized by aberrant lipid metabolism and a maladapted inflammatory response. Arterial inflammation is triggered by an insult to the endothelial lining, leading to activation of endothelial cells and recruitment of leukocytes, predominantly monocytes, to the vessel wall. The leukocyte recruitment cascade includes the initial captur...
متن کاملMonocytes Chat With Atherosclerotic Lesions
Atherosclerotic vascular disease is a chronic inflammation characterized by aberrant lipid metabolism and a maladapted inflammatory response. Arterial inflammation is triggered by an insult to the endothelial lining, leading to activation of endothelial cells and recruitment of leukocytes, predominantly monocytes, to the vessel wall. The leukocyte recruitment cascade includes the initial captur...
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Background—Atherosclerotic lesions are believed to grow via the recruitment of bone marrow–derived monocytes. Among the known murine monocyte subsets, Ly-6C monocytes are inflammatory, accumulate in lesions preferentially, and differentiate. Here, we hypothesized that the bone marrow outsources the production of Ly-6C monocytes during atherosclerosis. Methods and Results—Using murine models of ...
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Oxidatively modified lipoproteins have been implicated in atherogenesis, but the mechanisms that promote oxidation in vivo have not been identified. Myeloperoxidase, a heme protein secreted by activated macrophages, generates reactive intermediates that oxidize lipoproteins in vitro. To explore the potential role of myeloperoxidase in the development of atherosclerosis, we determined whether th...
متن کاملExtramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions.
BACKGROUND Atherosclerotic lesions are believed to grow via the recruitment of bone marrow-derived monocytes. Among the known murine monocyte subsets, Ly-6C(high) monocytes are inflammatory, accumulate in lesions preferentially, and differentiate. Here, we hypothesized that the bone marrow outsources the production of Ly-6C(high) monocytes during atherosclerosis. METHODS AND RESULTS Using mur...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2016
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.116.308176